The incidence of mental illpess in the modern society has been increasing and the use of the tranquilizer fo- the treatment of these illnesses has been increasing also.
The side `effects of the tranquilizer are reportedly, minimal and the long term use of the medicine is widely practised in this field.
But the question of its effect on cardiovascular system has been discussed previously and the level of cholesterol and triglyceride was found to increase in patients who have been on the tranquilizer for a long period of time.
The current study was undertaken to find out the effect of tranquilizer (chlorpromazine, thioridazine, perphenazine, haloperidol, and pimozide) given to the animals for 4 weeks.
And the results are summarized as follow:
1) In the animal group given chlorpromazine, thioridazine, and perphenazine, the level of total serum cholesterolwas increased and the activity of microsomal HMG-Co A reductase was also increased.
However, in the group given haloperidol and pimozide, there was no increase of cholesterol level or activity of microsomal HMG-Co A reductase.
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2) The correlation of serum total cholesterol level and the activity of HMG-Co A reductase in the liver` and brain was significant.
From the above results,, it could be concluded that the effect of the long term use of tranquilizer on the cardiovascular system should be reevaluated.
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